解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In predicting hierarchical protein function annotations, such as terms in the Gene Ontology (GO), the simplest approach makes predictions for each term independently. However, this approach has the unfortunate consequence that the predictor may assign to a single protein a set of terms that are inconsistent with one a...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-s1-s6
更新日期:2008-01-01 00:00:00
abstract::A report of The Keystone Symposium on Plant Innate Immunity, Keystone, USA, 10-15 February 2008. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb-2008-9-4-304
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Polydnaviruses, double-stranded DNA viruses with segmented genomes, have evolved as obligate endosymbionts of parasitoid wasps. Virus particles are replication deficient and produced by female wasps from proviral sequences integrated into the wasp genome. These particles are co-injected with eggs into caterp...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-12-r183
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Pseudogenes reveal ancestral gene functions. Some obligate intracellular bacteria, such as Mycobacterium leprae and Rickettsia spp., carry substantial fractions of pseudogenes. Until recently, horizontal gene transfers were considered to be rare events in obligate host-associated bacteria. RESULTS:We presen...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-2-r42
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Candidate single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWASs) were often selected for validation based on their functional annotation, which was inadequate and biased. We propose to use the more than 200,000 microarray studies in the Gene Expression Omnibus to systematically p...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-12-r170
更新日期:2008-01-01 00:00:00
abstract::Proteins of the phytochrome superfamily of red/far-red light receptors have a variety of biological roles in plants, algae, bacteria and fungi and demonstrate a diversity of spectral sensitivities and output signaling mechanisms. Over the past few years the first three-dimensional structures of phytochrome light-sensi...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2008-9-8-230
更新日期:2008-01-01 00:00:00
abstract::Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-9-r139
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Some years ago we established an N-ethyl-N-nitrosourea screen for modifiers of transgene variegation in the mouse and a preliminary description of the first six mutant lines, named MommeD1-D6, has been published. We have reported the underlying genes in three cases: MommeD1 is a mutation in SMC hinge domain ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-12-r182
更新日期:2008-01-01 00:00:00
abstract::A report of the 6th Georgia Tech-Oak Ridge National Lab International Conference on Bioinformatics 'In silico Biology: Gene Discovery and Systems Genomics', Atlanta, USA, 15-17 November, 2007. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb-2008-9-2-302
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Rice blast disease is caused by the filamentous Ascomycetous fungus Magnaporthe oryzae and results in significant annual rice yield losses worldwide. Infection by this and many other fungal plant pathogens requires the development of a specialized infection cell called an appressorium. The molecular processe...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-5-r85
更新日期:2008-01-01 00:00:00
abstract::A report on the Conference on Systems Biology of Mammalian Cells, Dresden, Germany, 22-24 May 2008. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb-2008-9-7-316
更新日期:2008-01-01 00:00:00
abstract::The nuclear genome sequence of Amborella trichopoda, the sister species to all other extant angiosperms, will be an exceptional resource for plant genomics. ...
journal_title:Genome biology
pub_type: 信件
doi:10.1186/gb-2008-9-3-402
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role for aberrant transcriptional regulation in AML pathophysiology. Although several transcription factors (TFs) involved in myeloid ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-2-r38
更新日期:2008-01-01 00:00:00
abstract::The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2008-9-9-232
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Trypanosoma brucei is the causative agent of human sleeping sickness and animal trypanosomiasis in sub-Saharan Africa, and it has been subdivided into three subspecies: Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause sleeping sickness in humans, and the nonhuman infective Trypano...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-6-r103
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Obligate pathogenic bacteria lose more genes relative to facultative pathogens, which, in turn, lose more genes than free-living bacteria. It was suggested that the increased gene loss in obligate pathogens may be due to a reduction in the effectiveness of purifying selection. Less attention has been given t...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r164
更新日期:2007-01-01 00:00:00
abstract::A new approach to rapid, genome-wide identification and ranking of horizontal transfer candidate proteins is presented. The method is quantitative, reproducible, and computationally undemanding. It can be combined with genomic signature and/or phylogenetic tree-building procedures to improve accuracy and efficiency. T...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-2-r16
更新日期:2007-01-01 00:00:00
abstract::Two landmark studies of cell signaling, by RNA interference and phosphoproteomics, provide complementary global views of the pathways downstream of receptor kinases, including those regulated by Erks. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-1-202
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Mutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster, disruption of RP genes can result in the 'Minute' syndrome of dominant, haploinsufficient phenotypes, which include prolonged dev...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-10-r216
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Xanthomonas campestris pathovar campestris (Xcc) is the causal agent of black rot disease of crucifers worldwide. The molecular genetic diversity and host specificity of Xcc are poorly understood. RESULTS:We constructed a microarray based on the complete genome sequence of Xcc strain 8004 and investigated t...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-10-r218
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Gene expression is a two-step synthesis process that ends with the necessary amount of each protein required to perform its function. Since the protein is the final product, the main focus of gene regulation should be centered on it. However, because mRNA is an intermediate step and the amounts of both mRNA ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-10-r222
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Gene duplication followed by divergence is one of the main sources of metabolic versatility. The patchwork and stepwise models of metabolic evolution help us to understand these processes, but their assumptions are relatively simplistic. We used a network-based approach to determine the influence of metaboli...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-2-r26
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Massively parallel pyrosequencing systems have increased the efficiency of DNA sequencing, although the published per-base accuracy of a Roche GS20 is only 96%. In genome projects, highly redundant consensus assemblies can compensate for sequencing errors. In contrast, studies of microbial diversity that cat...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-7-r143
更新日期:2007-01-01 00:00:00
abstract::How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensat...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2007-8-2-204
更新日期:2007-01-01 00:00:00
abstract::Normalization is critical for removing systematic variation from microarray data. For two-color microarray platforms, intensity-dependent lowess normalization is commonly used to correct relative gene expression values for biases. Here we outline a normalization method for use when the assumptions of lowess normalizat...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-1-r2
更新日期:2007-01-01 00:00:00
abstract::mtcPTM is an online repository of human and mouse phosphosites in which data are hierarchically organized to preserve biologically relevant experimental information, thus allowing straightforward comparisons of phosphorylation patterns found under different conditions. The database also contains the largest available ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-5-r90
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:DNA damage leads to cellular responses that include the increased expression of DNA repair genes, repression of DNA replication and alterations in cellular metabolism. Archaeal information processing pathways resemble those in eukaryotes, but archaeal damage response pathways remain poorly understood. RESUL...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-10-r220
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The embryo sac contains the haploid maternal cell types necessary for double fertilization and subsequent seed development in plants. Large-scale identification of genes expressed in the embryo sac remains cumbersome because of its inherent microscopic and inaccessible nature. We used genetic subtraction and...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-10-r204
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Nuclear factor I-A (NFI-A), a phylogenetically conserved transcription/replication protein, plays a crucial role in mouse brain development. Previous studies have shown that disruption of the Nfia gene in mice leads to perinatal lethality, corpus callosum agenesis, and hydrocephalus. RESULTS:To identify pot...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-5-r72
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The time of locus replication during S-phase is tightly regulated and correlates with chromatin state. Embryonic stem (ES) cells have an unusual chromatin profile where many developmental regulator genes that are not yet expressed are marked by both active and repressive histone modifications. This poised or...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r169
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:We describe the distribution of indels in the 44 Encyclopedia of DNA Elements (ENCODE) regions (about 1% of the human genome) and evaluate the potential contributions of small insertion and deletion polymorphisms (indels) to human genetic variation. We relate indels to known genomic annotation features and m...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-9-r180
更新日期:2007-01-01 00:00:00
abstract::Swine production has been an important part of our lives since the late Mesolithic or early Neolithic periods, and ranks number one in world meat production. Pig production also contributes to high-value-added medical markets in the form of pharmaceuticals, heart valves, and surgical materials. Genetic engineering, in...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2007-8-s1-s13
更新日期:2007-01-01 00:00:00
abstract::DNA transposons are efficient tools in transgenesis and have therefore become popular in the analysis of the regulatory genome in vertebrates via enhancer trap screens. Here, I discuss recent progress in this field of research, with a focus on the application of one of these transposons, namely the medaka fish derived...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2007-8-s1-s8
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition. So far, identification of miRNAs has been limited to a few model plant species, such as Arabidopsis, rice and Populus, whose genomes have been sequenc...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-6-r96
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:It has been hypothesized that rapid divergence in centromere sequences accompanies rapid karyotypic change during speciation. However, the reuse of breakpoints coincident with centromeres in the evolution of divergent karyotypes poses a potential paradox. In distantly related species where the same centromer...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r170
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Is it possible to construct an accurate and detailed subgene-level map of a genome using bacterial artificial chromosome (BAC) end sequences, a sparse marker map, and the sequences of other genomes? RESULTS:A sheep BAC library, CHORI-243, was constructed and the BAC end sequences were determined and mapped ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-7-r152
更新日期:2007-01-01 00:00:00
abstract::Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes, whether they a...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-8-r155
更新日期:2007-01-01 00:00:00
abstract::Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-2-r23
更新日期:2007-01-01 00:00:00
abstract::The first highly specific knockouts of a microRNA, miR155, in mice result in multiple defects in adaptive immunity, and also show the feasibility of investigating at least some microRNAs by gene knockout. ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2007-8-7-221
更新日期:2007-01-01 00:00:00
abstract::We propose a novel approach for finding a list of features that are commonly perturbed in two or more experiments, quantifying the evidence of dependence between the experiments by a ratio. We present a Bayesian analysis of this ratio, which leads us to suggest two rules for choosing a cut-off on the ranked list of p ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-4-r54
更新日期:2007-01-01 00:00:00